Preparation And Standardization Of Volumetric Solution SOP
1.0 OBJECTIVE:
To
lay down the procedure for preparation and standardization of volumetric
solution.
2.0 SCOPE:
This
SOP shall be applicable to Quality Control dept.
3.0 RESPONSIBILITY:
3.1
Supervisor Quality Control.
4.0 ACCOUNTABILITY:
4.1
Sr. Manager Q.A.
4.2
Head of the Q.C Department.
5.0 PROCEDURE:
5.1
Maintain the register for preparation and
standardization of volumetric solutions.
5.2
Allocate at least 3 pages for each
volumetric solution. Write the name of volumetric solution on the Top of the
pages.
5.3
Prepare an index of all the volumetric
solutions on the first page of the register.
5.4
Prepare the table for every solution
giving details of date of preparation, use before date, date of standardization/
re-standardization, standardized by along with other relevant details.
5.5
Prepare a sufficient volume of each
volumetric solution to last for about three months, store it in a glass
stoppered bottle, label it properly and keep it in specified rack. Do not store
the stock solution on the work bench.
5.6
Before using any volumetric solution,
shake the solution well in order to mix the drops of water condensed on the top
and sides of the bottles with the solution in the bottle.
5.7
Wherever drying of primary standard is
required by the procedure for standardization, primary standards shall be dried
at specified temperature.
5.8
Carry out the standardization three times.
The results should not differ by more than 0.5%. In case the standard deviation
is more than 0.5%, repeat the standardization afresh.
5.9
Record the normality/ molarity of the
solution in the record register.
5.10
The volumetric solution should not be used
after 3 month from date of preparation. Re-standardization the volumetric
solution every fifteen days.
5.11
Volumetric solution should be labeled
properly and label should contain the following details:
5.11.1 Name
of reagent/ solution.
5.11.2 Strength.
5.11.3 Actual
molarity/ normality.
5.11.4 Prepared
by name.
5.11.5 Date
of preparation.
5.11.6 To
be used before.
5.11.7 Date
of standardization/ re-standardization.
5.11.8 Valid
until.
5.11.9 Signature.
6.0 REVISION LOG:
|
Revision No. |
Effective Date |
Reason |
|
00 |
01/07/2020 |
New
SOP |
7.0 REFERENCES:
7.1
Not Applicable.
8.0 ANNEXURES:
8.1
Not Applicable.
9.0 ABBREVIATIONS:
|
Abbreviation |
Expanded Form |
|
S
|
Standard
operating procedure |
|
& |
And
|
|
% |
percentage |