SOP for Checking the Sieve Integrity

 In this post Standard Operating Procedure of SOP for Checking the Sieve Integrity  in Pharmaceuticals is describe.

Purpose: To lay down operating procedure for the operation of checking the sieve integrity

Scope: This procedure is applicable for ................

Responsibility: Production Chemist

                            To supervise the activity

Procedure:

1. Take the specified sieve as per Batch Manufacturing Record from the Clean equipment room.

2. Before arranging, visually check the cleaning status & sieve integrity.

3. After operation is completed, dismantle the sieve & transfer to the Cleaning area.

4. Flush the sieve with water & clean with the help of wet cloth.

5. Dry with a clean cloth & observe any residue of previous product.

6. Check the integrity of sieve visually.

7. Separate the damaged sieve & label it as NOT FOR USE.

8. After completely dried, wrap the sieves in a clean polythene bag

9. Transfer the inspected sieves in clean equipment room.

10. Perform the inspection daily for all sieves of sifter & multi mill.

11. Record the entire activities in Daily Sieve Checking Record.

Precautions:

1. Care should be taken during cleaning. The sieves should not be

pressed excessively as it can damage the sieve integrity.

2. Care should be taken during the sifting of hydrophobic materials, as they are difficult to remove.

3. Do not press the sieves excessively during sifting operation to avoid damage. In case the sieve is damaged, immediately replace the sieve to avoid the future risk of contamination of the product.

5. The sieve should be checked regularly & record should be maintained.

ANNEXURE I

DAILY SIEVE CHECKING RECORD