Title: Standard operating procedure for
determination of Melting point of given sample by using melting point
apparatus.
1.0
OBJECTIVE:
To lay down a procedure of Melting
point of given sample by using melting point apparatus.
2.0
SCOPE:
This SOP shall be applicable to Q.C
Dept.
3.0
RESPONSIBILITY:
3.1 Doing: Q.C Analyst.
3.2 Checking: Q.C-Manager.
4.0
ACCOUNTABILITY:
4.1 Head of the Q.C Department.
5.0
MATERIAL AND EQUIPMENT:
5.1 Melting point apparatus.
5.2 Capillary tubes.
5.3 Burner.
5.4 Spatula.
6.0
PROCEDURE:
6.1 Unless otherwise prescribed, dry the
finely powdered substance in vacuo and over the anhydrous silica gel for 24
hrs.
6.2 Introduce the sufficient quantity of
sample into a capillary tube.
6.3 Set the apparatus and immerse the
capillary tube into the apparatus such that the closed end is near the centre
of the bulb of thermometer.
6.4 Switch on the melting point apparatus.
6.5 Operate the melting point apparatus
according to the SOP.
6.6 Raise the temperature of the apparatus.
6.7 Record the temperature at which the
last particle passes into the liquid phase.
6.8 Record measurements in annexure-1.
7.0
REVISION LOG:
|
Revision No. |
Effective Date |
Reason |
|
00 |
|
New
SOP |
8.0
REFERENCES:
8.1 Not Applicable.
9.0
ANNEXURES:
Annexure
1: Observations of Melting point apparatus.
Annexure: 1
Observations of Melting point apparatus
Sample = _____________
Time period = _____________
|
Sr.# |
Initial
(Ti) (oC) |
Final
(Tf) (oC) |
Tf
- Ti (oC) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Average: _____________
Result:
_________________
Remarks:
__________________________________________________