Biochemistry 8th  Jeremy M. Berg, John L. Tymoczko, Gregory J., Gatto & Jr.Lubert Stryer

Biochemistry 8th  Jeremy M. Berg, John L. Tymoczko, Gregory J., Gatto & Jr.Lubert Stryer

For several generations of students and teachers, Biochemistry has been an invaluable resource, pre-senting the concepts and details of molecular structure, metabolism, and laboratory techniques in a streamlined and engaging way. Biochemistry’s success in helping students learn the subject for the first time is built on a number of hallmark features:

Clear writing and simple illustrations. The lan-guage of biochemistry is made as accessible as possi-ble for students learning the subject for the first time. To complement the straightforward language and organization of concepts in the text, figures illustrate a single concept at a time to help students see main points without the distraction of excess detail.

Physiological relevance. It has always been our goal to help students connect biochemistry to their own lives on a variety of scales. Pathways and pro-cesses are presented in a physiological context so

students can see how biochemistry works in the body and under different conditions, and Clinical Application sections in every chapter show students how the concepts they are studying impact human health. The eighth edition includes a number of new Clinical Application sections based on recent dis-coveries in biochemistry and health. (For a full list, see p. xi)

Evolutionary perspective. Discussions of evolution are woven into the narrative of the text, just as evolu-tion shapes every pathway and molecular structure described in the text. Molecular Evolution sections highlight important milestones in the evolution of life as a way to provide context for the processes and molecules being discussed. (For a full list, see p. x)

Problem-solving practice. Every chapter of Biochemistry provides numerous opportunities for students to practice problem-solving skills and apply the concepts described in the text. End-of-chapter problems are divided into three categories to address different problem-solving skills: Mechanism prob-lems ask students to suggest or describe a chemical mechanism; Data interpretation problems ask stu-dents to draw conclusions from data taken from real research papers; and chapter integration problems require students to connect concepts from across chapters. Further problem-solving practice is pro-vided online, on the Biochemistry LaunchPad. (For more details on LaunchPad resources, see p. viii)

A variety of molecular structures. All molecular structures in the book, with few exceptions, have been selected and rendered by Jeremy Berg and Gregory Gatto to emphasize the aspect of structure most impor-tant to the topic at hand. Students are introduced to realistic renderings of molecules through a molecular model “primer” in the appendices to Chapters 1 and 2 so they are well-equipped to recognize and interpret the structures throughout the book. Figure legends direct students explicitly to the key features of a model, and often include PDB numbers so the reader can access the file used in generating the structure from the Protein Data Bank website ( Students

Figure 9.48 Single molecule motion. (A) A trace of the position of a single dimeric myosin V molecule as it moves across a surface coated with actin filaments. (B) A model of how the dimeric molecule moves in discrete steps with an average size of 74 6 5 nm. [Data from A. Yildiz et al., Science 300(5628)2061–2065, 2003.]

can explore molecular structures further online through the Living Figures, in which they can rotate 3D models of molecules and view alternative renderings.

In this revision of Biochemistry, we focused on build-ing on the strengths of the previous editions to present biochemistry in an even more clear and streamlined manner, as well as incorporating exciting new advances from the field. Throughout the book, we have updated explanations of basic concepts and bolstered them with examples from new research. Some new topics that we present in the eighth edition include:

Environmental factors that influence human  biochemistry (Chapter 1)

Genome editing (Chapter 5)

Horizontal gene transfer events that may explain unex-pected branches of the evolutionary tree (Chapter 6)

Penicillin irreversibly inactivating a key enzyme in bacterial cell-wall synthesis (Chapter 8)

Scientists watching single molecules of myosin move (Chapter 9)

Glycosylation functions in nutrient sensing

(Chapter 11)

The structure of a SNARE complex (Chapter 12)

The mechanism of ABC transporters (Chapter 13)

The structure of the gap junction (Chapter 13)

The structural basis for activation of the b-adrenergic receptor (Chapter 14)

Excessive fructose consumption can lead to patho-logical conditions (Chapter 16)

Alterations in the glycolytic pathway by cancer cells (Chapter 16)

Regulation of mitochondrial ATP synthase

(Chapter 18)

Control of chloroplast ATP synthase (Chapter 19)

Activation of rubisco by rubisco activase (Chapter 20)

The role of the pentose phosphate pathway in rapid cell growth (Chapter 20)

Biochemical characteristics of muscle fiber types (Chapter 21)

Alteration of fatty acid metabolism in tumor cells (Chapter 22)

Biochemical basis of neurological symptoms of  phenylketonuria (Chapter 24)

Ribonucleotide reductase as a chemotherapeutic  target (Chapter 25)

The role of excess choline in the development of heart disease (Chapter 26)

Cycling of the LDL receptor is regulated (Chapter 26)

The role of ceramide metabolism in stimulating tumor growth (Chapter 26)

The extraordinary power of DNA repair systems illustrated by Deinococcus radiodurans (Chapter 28)

The structural details of ligand binding by TLRs

(Chapter 34)


 1 Biochemistry: An Evolving Science 1

 2 Protein Composition and Structure 27

 3 Exploring Proteins and Proteomes 65

 4 DNA, RNA, and the Flow of Genetic Information 105  5 Exploring Genes and Genomes 135

 6 Exploring Evolution and Bioinformatics 169

 7 Hemoglobin: Portrait of a Protein in Action 191

 8 Enzymes: Basic Concepts and Kinetics 215

 9 Catalytic Strategies 251

10 Regulatory Strategies 285

11 Carbohydrates 315

12 Lipids and Cell Membranes 341

13 Membrane Channels and Pumps 367

14 Signal-Transduction Pathways 397


15 Metabolism: Basic Concepts and Design 423

16 Glycolysis and Gluconeogenesis 449

17 The Citric Acid Cycle 495

18 Oxidative Phosphorylation 523

19 The Light Reactions of Photosynthesis 565

20 The Calvin Cycle and the Pentose Phosphate 

Pathway 589

21 Glycogen Metabolism 617

22 Fatty Acid Metabolism 643

23 Protein Turnover and Amino Acid Catabolism 681


24 The Biosynthesis of Amino Acids 713

25 Nucleotide Biosynthesis 743

26 The Biosynthesis of Membrane Lipids and 

Steroids 767

27 The Integration of Metabolism 801

28 DNA Replication, Repair, and Recombination 827 29 RNA Synthesis and Processing 859

30 Protein Synthesis 893

31 The Control of Gene Expression in Prokaryotes 925 32 The Control of Gene Expression in Eukaryotes 941 Part IV  RESPONDING TO ENVIRONMENTAL 


33 Sensory Systems 961 34 The Immune System 981 35 Molecular Motors 1011 36 Drug Development 1033



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