Pharmaceutical Analysis Nirali Parkashan
The is is the first edition of a text book in Pharmaceutical Analysis intended for students of Pharmaceutical sciences. This book can serve as an excellent tool for learning pharmaceutical analysis in the undergraduate curriculum prescribed by the Pharmacy Council of India. The objective of this book is to provide and update knowledge on each to pic of pharmaceutical analysis. The concept of pharmaceutical analysis is complex which needs to be explained well, at the same time the simplicity of concept is to be more focused considering the understanding levels of the undergraduate students. This book is written considering the above thought and concepts on said topics, and have been presented in simple language without compromising qulatily of both language and concepts. The book was written by referring the concepts from renowned reference books, latest articles publish ed in journals and from the own experience of authors to provide updated information.
Pharmaceutical Analysis" is a comprehensive compilation of 5 Units as per the structure designed by Pharmacy council of India which covers the basic principles, technique, applications of various analytical techniques in addition to the recent information about Indian Pharmacopoeia and its monograph. The beauty of the book is that the late st information including the applications of techniques from the data is concise considering the syllabus and number of lectures provided. Thus, students get exposure of exact concept of each topic. Every chapter includes learning objectives of the unit and quest i o n bank containing probable questions, to help students to prepare better for the examinations .
We hope that, the is book would be a handy nutshell for all the student s as well as the teachers teaching the subject of Pharmaceutical Analysis.
We are thankful to Publish er Shri. Jignesh Furia and the entire staff of Nirali Prakashan, specially Mr. Malik Shaikh, Mrs. Manasi Pingle, Mr. Ravindra Walodare an d M s. Chaitali Takale for their co-operation in bringing this book in time.
We shall be grateful to all the teachers and students to provide us valuable suggestions to imp rove the quality of the book in future.
UNIT - I
(a) Pharmaceutical analysis: Definition and scope.
(i) Different techniques of analysis .
(ii) Methods of expressing concentration.
(iii) Primary and secondary standards.
(iv) Preparation and standardization of various molar and normal solutions - Oxalic acid , sodium hydroxide, hydrochloric acid, sodium thiosulphate, sulphuric acid, potassium permanganate and eerie ammonium sulphate.
(b) Errors: Sources of errors, types of errors , methods of minimizing error s, accuracy, precision and significant figures
(c) Pharmacopoeia, sources of impurities in medicinal agents, limit tests .
UNIT - II
Acid-base titration: Theories of acid-base indicators, classification of acid base titrations and theory involved in titrations of strong, weak, and very weak acids and bases, neutralization curves.
Non-aqueous titration: Solvents, acid imetry and alkalimet rytitration and estimation of sodium benzoate and ephedrine HCI.
UNIT - Ill
Precipitation titrations: Mohr's method, Volhard's, Modified Volhard's , Fajans method, estimation of sodium chloride.
Complexometric titration: Classification , metalion indicat ors, mas king and demasking reagents, estimation of magnesium sulphate and calcium gluconate.
Gravimetry: Principle and steps involved in gravimetric analysis, purity of the precipitate, co-precipitation and post precipitation, estimation of barium sulphate.
Basic Principles, methods and application of diazotisation titration.
UNIT - IV
Redoxtitrations
(a) Concepts of oxidation and reduct on
(b) Types of redox titrations (Principles and applications)
Cerimetry, Iodimetry, Iodometry, Bromatometry, Dichrometry, Titration with pota ssiumiodate.
UNIT - V
Electrochemical methods of analysis:
Conductometry: Introduction, conductivity cell , conductometric titrations , applications. Potentiometry: Electrochemical cell, construction and working of reference (Standard hydrogen, silver chloride electrode and calomel electrode) and indicator electrodes (metal electrodes and glass electrode), methods to determine end point of potention metrictitration and applications.
Polarography: Principle, Ilkovic equation , construction and working of dropping mercury elect rode and rotating plat in um elect rode, app licat ions.
