The sixth edition of Brody's Human Pharmacology has been appropriately subtitled Mechanism-Based Therapeutics and has been designed to provide students in all health professions with pharmacological information and its clinical relevance.

A major goal of this edition has been to present information in the clearest and most concise manner, using prototypical drugs to illustrate basic mechanisms and boxes and tables to emphasize key points and relevant clinical information, with many new figures within each section.

Sections were created with a focus on therapeutics, and two new sections were added to this edition, including one on drug therapy for pain management and another on the treatment of inflammatory, allergic, and immunological disorders. In addition, several new chapters have been added to this edition including

 

·         A chapter on pharmacogenetics in the Therapeutic Principles Section, critical in this era of personalized medicine

·         A chapter on the cannabinoids in the Pain Management Section, particularly important in light of the opioid crisis

·         A chapter focused on drugs for the treatment of attention deficit hyperactivity disorder in the Central Nervous System Section, because these medications are being prescribed to an increasing number of children

·         A chapter on drug treatment for human immunodeficiency virus and related opportunistic infections in the Chemotherapy Section, because millions of individuals are dying each year from AIDS-related illnesses.

Chapters were formatted using a consistent style and include the following section titles:

       

Therapeutic Overview

Mechanisms of Action

Relationship of Mechanisms of Action to Clinical Response Pharmacokinetics

Pharmacovigilance: Adverse Effects and Drug Interactions

 

In addition, a chapter section titled New Developments presents the latest advancements in the field and may include discussions of drugs being investigated or developed as new information is gained. Another new section titled Clinical Relevance for Healthcare Professionals provides relevant information applicable to all professionals in the healthcare field, as well as clinically important information for specific professionals such as physical therapists, dentists, and nurses.

Many of the figures have been revised to more clearly illustrate the textual information and assist students in learning. As the number of drugs in each drug class has increased, an emphasis has been placed on major drug classes relevant to each chapter, with generic and trade-named materials presented at the end of each chapter.

As with prior editions, the multicolored figures explaining key concepts will be available on Student Consult.

I sincerely hope that the content revisions and additions, consistent organization, and new figures are helpful to both students and teachers of pharmacology in all health professions.



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