|
Bill of Materials
|
|||
|
Scale
(mg/tablet)
|
Item
|
Material
Name
|
Quantity/1000
Tablets (g)
|
|
250.00
|
1
|
Chloroquine
diphosphate
|
250.00
|
|
100.00
|
2
|
Dicalcium
phosphate (Ditab)
|
100.00
|
|
10.00
|
3
|
Kollidon 30
|
10.00
|
|
—
|
4
|
Isopropyl alcohol
|
83.00
|
|
10.00
|
5
|
Kollidon CL
|
10.00
|
|
2.00
|
6
|
Aerosil 200
|
2.00
|
|
3.00
|
7
|
Talc
|
3.00
|
Manufacturing Directions
1. Granulate the mixture of items 1 and 2 with a solution of items 3 and 4. Then dry, pass through a 0.8-mm sieve, add the mixture of items 5 to 7, and press with low- compression force.
2. Compress into 361-mg tablets, using 8-mm biplanar punches.