Pressure Tank for Coating operation SOP

1.0  OBJECTIVE:

To lay down the operation procedure for Pressure vessel, peristaltic pump and spraying gun.

2.0  SCOPE:

This SOP shall be applicable for the operation of Pressure vessel, peristaltic pump and spraying gun in Coating Room of Production department.

3.0  RESPONSIBILITY:

3.1  Supervisor/ Machine Operator.

3.2  Production Pharmacist & above.

4.0  ACCOUNTABILITY:

4.1  Manager-Production department.

5.0  MATERIAL AND EQUIPMENT:

5.1  Pressure vessel, peristaltic pump and spraying gun.

6.0  PROCEDURE:

6.1  Assure the cleanliness of the coating pan.

6.2  Charge the core tablets into the pan.

6.3  Set atomization air limit switch. This will set ‘OFF’ spray system if atomization air pressure falls below set air pressure manually.

6.4  Remove the lid of the liquid vessel and load the coating solution of required quantity. Close the lid of the liquid vessel. Activate the stirrer by opening the compressed air supply knob.

6.5  Set the dosing percentage of the feed pump as per requirement by rotating the knob provided on the top of the pump.

6.6  Set  the spray gun for liquid volume flow and spray pattern as follows:

6.6.1        Put ‘OFF’ the compressed air supply valve of atomization air.

6.6.2        Press the selector switch on PDM bypass.

6.6.3        Press the selector switch on ‘Manual’ position.

6.7  Start the pan, inlet damper & then start exhaust blower maintain the bed temperature as per BMR by pressing the heater ‘ON’ position.

6.8  Press the hot air blower switch to start hot air blower.

6.9  Start coating pan & adjust the distance between tablet bed & gun.

6.10                            Introduce the spray gun assembly into the coating pan. Keep the gun to the tablet bed distance between 8-12cm for non-aqueous coating & for aqueous coating 7-10cm. Then close the lock the front window.

6.11                            Check the weight of 20 core tablet before loading & after drying & finally check the weight gain.

6.12                            After completion of operation. Put ‘OFF’ the mains.

6.13                            Affix ‘To be Cleaned’ status label.

6.14                            And fill the ‘Equipment Log Book.’

7.0  REVISION LOG:

Revision No.	Effective Date	Reason
00		New SOP

8.0  REFERENCES:

8.1  Not Applicable.

9.0  ANNEXURES:

9.1  Not Applicable.

10.0    ABBREVIATIONS:

Abbreviation	Expanded Form
SOP	Standard operating procedure
&	And
No.	Number
Ltd.	Limited
PM	Production machinery
PMO	Production machinery operation
F	Format
cm	Centimeter
BMR	Batch manufacturing record