Aceclofenac International Brand (Medicinal Forms)

Aceclofenac International Brand (Medicinal Forms)

INDICATIONS AND DOSE:

Pain and inflammation in rheumatoid arthritis,

osteoarthritis and ankylosing spondylitis

▶ BY MOUTH

▶ Adult: 100 mg twice daily

CONTRA-INDICATIONS

Active gastro-intestinal bleeding .active gastro-intestinal ulceration . cerebrovascular disease . history of gastro-intestinal bleeding related to previous NSAID therapy . history of gastro-intestinal perforation related to previous NSAID therapy . history of recurrent gastro-intestinal haemorrhage (two or more distinct episodes) . history of recurrent gastro-intestinal ulceration (two or more distinct episodes) . ischaemic heart disease . mild heart failure . peripheral arterial disease . severe heart failure

CAUTIONS

Allergic disorders . avoid in Acute porphyrias p. 1025 . cardiac impairment (NSAIDs may impair renal function) . coagulation defects . connective-tissue disorders . Crohn’s disease (may be exacerbated) . elderly (risk of serious side-effects and fatalities) . history of cardiac failure . hypertension . left ventricular dysfunction . oedema . risk factors for cardiovascular events . ulcerative colitis (may be exacerbated)

SIDE EFFECT

▶ Common or very common Diarrhoea . dizziness . gastrointestinal discomfort . nausea

▶ Uncommon Constipation . gastrointestinal disorders . oraldisorders . skin reactions . vomiting

▶ Rare or very rare Anaemia . angioedema . bone marrow disorders . depression . drowsiness . dyspnoea . fatigue . haemolytic anaemia . haemorrhage . headache . heartfailure . hepatic disorders . hyperkalaemia . hypersensitivity . hypertension . inflammatory bowel disease . leg cramps . nephrotic syndrome . neutropenia . oedema . palpitations . pancreatitis . paraesthesia . renal failure (more common in patients with pre-existing renal impairment) . respiratory disorders . severe cutaneous adverse reactions (SCARs) . sleep disorders . taste altered . thrombocytopenia . tinnitus . tremor . vasculitis . vasodilation . vertigo . visual impairment . weight increased

▶ Frequency not known Acute coronary syndrome . agranulocytosis . asthma . confusion . hallucination . increased risk of arterial thromboembolism . increased risk of ischaemic stroke . malaise . meningitis aseptic (patients with connective-tissue disorders such as systemic lupus erythematosus may be especially susceptible) . nephritis tubulointerstitial . optic neuritis . photosensitivity reaction . platelet aggregation inhibition . respiratory tract reaction

SIDE-EFFECTS, FURTHER INFORMATION For information about cardiovascular and gastrointestinal side-effects, and a possible exacerbation of symptoms in asthma, see Nonsteroidal anti-inflammatory drugs p. 1094

International Brands (Medicinal Forms)

Sr. #	Brand Name	Dosage Form	Pack Size	Price	Manufacturer
1.	Preservex 100mg	Aceclofenac 100 mg	60 capsule	£9.63	Almirall Ltd

Reference:

BNF 74, Page No. 1096