Abacavir International Brand
INDICATIONS
AND DOSE
INDICATIONS AND DOSE:
|
HIV infection in combination with other
antiretroviral drugs.
BY MOUTH.
Adult: 600 mg daily in 1–2 divided doses
HIV load greater than 100 000 copies/mL
. patients at high risk of cardiovascular disease (especially if 10-year
cardiovascular risk greater than 20%)
Appendix 1: abacavir
SIDE-EFFECTS
|
Very rare Stevens-Johnson syndrome. toxic epidermal necrolysis
▶ Frequency not known Hypersensitivity reactions
SIDE-EFFECTS, FURTHER INFORMATION
|
Hypersensitivity
reactions Life-threatening hypersensitivity reactions reported—characterised by
fever or rash and possibly nausea, vomiting, diarrhoea, abdominal pain, dyspnoea,
cough, lethargy, malaise, headache, and myalgia; less frequently mouth
ulceration, oedema, hypotension, sore throat, acute respiratory distress syndrome,
anaphylaxis, paraesthesia, arthralgia, conjunctivitis, lymphadenopathy,
lymphocytopenia and renal failure; rarely myolysis; laboratory abnormalities
may include
raised liver function tests and creatine kinase; symptoms usually appear in the
first 6 weeks, but may occur at any time.610 Viral infection BNF 74 Infection 5
Discontinue immediately if any symptom of hypersensitivity develops and do not
rechallenge (risk of more severe hypersensitivity reaction); discontinue if hypersensitivity
cannot be ruled out, even when other
diagnoses
possible—if rechallenge necessary it must be carried out in hospital setting;
if abacavir is stopped for any reason other than hypersensitivity, exclude hypersensitivity
reaction as the cause and rechallenge only if medical assistance is readily
available; care needed with concomitant use of drugs which cause skin toxicity.
▶
Gastro-intestinal disturbances More common in children.
▶ Rash More
common in children.
International Brands
|
Sr. #
|
Brand Name
|
Dosage Form
|
Pack Size
|
Price
|
Manufacturer
|
1
|
ZIAGEN
20mg/ml
|
Oral
Solution sugar-free
|
240ml
|
£47.36
|
ViiV
Healthcare UK Ltd
|
2
|
ZIAGEN
300mg
|
Tablet
|
60
Tablet
|
£177.60
|
ViiV
Healthcare UK Ltd
|
Reference:
BNF
74, Page No. 610