Abacavir International Brand
INDICATIONS
AND DOSE
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INDICATIONS AND DOSE:
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HIV infection in combination with other
antiretroviral drugs.
BY MOUTH.
Adult: 600 mg daily in 1–2 divided doses
HIV load greater than 100 000 copies/mL
. patients at high risk of cardiovascular disease (especially if 10-year
cardiovascular risk greater than 20%)
Appendix 1: abacavir
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SIDE-EFFECTS
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Very rare Stevens-Johnson syndrome. toxic epidermal necrolysis
▶ Frequency not known Hypersensitivity reactions
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SIDE-EFFECTS, FURTHER INFORMATION
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Hypersensitivity
reactions Life-threatening hypersensitivity reactions reported—characterised by
fever or rash and possibly nausea, vomiting, diarrhoea, abdominal pain, dyspnoea,
cough, lethargy, malaise, headache, and myalgia; less frequently mouth
ulceration, oedema, hypotension, sore throat, acute respiratory distress syndrome,
anaphylaxis, paraesthesia, arthralgia, conjunctivitis, lymphadenopathy,
lymphocytopenia and renal failure; rarely myolysis; laboratory abnormalities
may include
raised liver function tests and creatine kinase; symptoms usually appear in the
first 6 weeks, but may occur at any time.610 Viral infection BNF 74 Infection 5
Discontinue immediately if any symptom of hypersensitivity develops and do not
rechallenge (risk of more severe hypersensitivity reaction); discontinue if hypersensitivity
cannot be ruled out, even when other
diagnoses
possible—if rechallenge necessary it must be carried out in hospital setting;
if abacavir is stopped for any reason other than hypersensitivity, exclude hypersensitivity
reaction as the cause and rechallenge only if medical assistance is readily
available; care needed with concomitant use of drugs which cause skin toxicity.
▶
Gastro-intestinal disturbances More common in children.
▶ Rash More
common in children.
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International Brands
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Sr. #
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Brand Name
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Dosage Form
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Pack Size
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Price
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Manufacturer
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1
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ZIAGEN
20mg/ml
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Oral
Solution sugar-free
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240ml
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£47.36
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ViiV
Healthcare UK Ltd
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2
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ZIAGEN
300mg
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Tablet
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60
Tablet
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£177.60
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ViiV
Healthcare UK Ltd
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Reference:
BNF
74, Page No. 610