Chloroquine Phosphate 250mg Tablet Formulations





Bill of Materials
Scale (mg/tablet)
Item
Material Name
Quantity/1000 Tablets (g)
250.00
1
Chloroquine diphosphate
250.00
100.00
2
Dicalcium phosphate (Ditab)
100.00
10.00
3
Kollidon 30
10.00
4
Isopropyl alcohol
83.00
10.00
5
Kollidon CL
10.00
2.00
6
Aerosil 200
2.00
3.00
7
Talc
3.00

Manufacturing Directions

1. Granulate the mixture of items 1 and 2 with a solution of items 3 and 4. Then dry, pass through a 0.8-mm sieve, add the mixture of items 5 to 7, and press with low- compression force.

2. Compress into 361-mg tablets, using 8-mm biplanar punches.

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